1. ChIP-seq analyses in primary endometrial tissue.
ChIP-seq analyses in primary endometrial tissue. (A) Genome browser snapshots of ERα and H3K27ac sites in endometrial tumors, in FA-fixed samples with and without DSG treatment (FA: blue. FA+DSG: red). (B) Venn diagram showing the overlap of sites for ERα and H3K27ac using FA (blue) and FA along with DSG (red). (C) Intensity plots showing the read densities over the peaks (±5 kb) in profiles generated using FA (−) and FA along with DSG (+). The fraction of reads in peaks (FRiP score) is placed above each intensity plot. (D) Genomic distribution of sites for ERα and H3K27ac in FA/DSG fixed samples (FA+DSG). (E) Percentage sites of ERα sites in FA/DSG fixed samples positive for ESR1 motifs. (F) Venn diagram of union of all ERα sites previously reported in endometrial tumors and sites identified in FA/DSG-fixed samples. The intensity plot shows the read density of the previously published ERα binding sites (±5 kb).
Abhishek A Singh et al. LSA 2019;2:e
© 2018 Singh et al.