1. Immune Quiescence and Hepatitis B Virus: Tolerance Has Its Limits
Victoria M. Velazquez, Arash Grakoui 
Gastroenterology 
Volume 143, Issue 3, Pages (September 2012)
DOI: /j.gastro
Copyright © 2012 AGA Institute Terms and Conditions

2. Figure 1
The natural progression of CHB through phases of (i) tolerance, (ii) activation, and (iii) control. Although T-cell priming during the tolerant phase of CHB is not thought to occur, Kennedy et al3 demonstrate a clear distinction between the presence of HBV-specific T cells (dashed red) and actual control of viral replication (solid red). This distinction is most exaggerated in younger patients. Potential mechanisms that might contribute to a ‘quiescent’ state of the newly discovered T-cell responses in vivo are highlighted.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2012 AGA Institute Terms and Conditions