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Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation  Estebe J.-P. , Gentili M.E. , Le Corre.

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Presentation on theme: "Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation  Estebe J.-P. , Gentili M.E. , Le Corre."— Presentation transcript:

1 Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation  Estebe J.-P. , Gentili M.E. , Le Corre P. , Leduc C. , Moulinoux J.-P. , Ecoffey C.   British Journal of Anaesthesia  Volume 93, Issue 5, Pages (November 2004) DOI: /bja/aeh264 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Time course of mean pressure withdrawal threshold (cut-off 600 mm Hg) was evaluated on the right paw after infiltration of carrageenan (ipsilateral evaluation) and after right sciatic injection of saline, bupivacaine 1.25 mg, bupivacaine 12.5 mg as bupivacaine-loaded microspheres in suspension of dexamethasone, amitriptyline 6.25 mg and amitriptyline 12.5 mg, and after intraperitoneal injection of amitriptyline. n=10 in each group. Mean (sd). British Journal of Anaesthesia  , DOI: ( /bja/aeh264) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Time course of mean pressure withdrawal threshold was evaluated on the left paw after carrageenan infiltration of the contralateral paw (right paw) and after right sciatic injection of saline, bupivacaine 1.25 mg, bupivacaine 12.5 mg as bupivacaine-loaded microspheres in suspension of dexamethasone, amitriptyline 6.25 mg and amitriptyline 12.5 mg, and after intraperitoneal injection of amitriptyline. n=10 in each group. Mean (sd). British Journal of Anaesthesia  , DOI: ( /bja/aeh264) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions


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