1. Personalized Medicine for Pancreatic Cancer: A Step in the Right Direction 
Andrew H. Ko, Margaret A. Tempero 
Gastroenterology 
Volume 136, Issue 1, Pages (January 2009)
DOI: /j.gastro
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2. Figure
Gemcitabine uptake and metabolism. Gemcitabine (2′,2′-difluorodeoxycytidine) is taken up into cells by nucleoside transporters and sequentially phosphorylated into active forms. The initial phosphorylation by DCK is the rate-limiting step. The proteins in boldface represent potentially useful biomarkers that may predict for gemcitabine sensitivity and resistance ENT1, equilibrative nucleoside transporter 1; CNT1 and CNT3, concentrative nucleoside transporters 1 and 3; DCK, deoxycytidine kinase; CDA, cytidine deaminase; RRM1/2, ribonucleotide reductase (subunits 1 and 2); DCTD, deoxycytidine monophosphate deaminase).
Gastroenterology  , 43-45DOI: ( /j.gastro )
Copyright © 2009 AGA Institute Terms and Conditions