1. Volume 140, Issue 7, Pages 1943-1951 (June 2011)
The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome 
Lisa A. Kilpatrick, Jennifer S. Labus, Kristen Coveleskie, Christian Hammer, Gudrun Rappold, Kirsten Tillisch, Joshua A. Bueller, Brandall Suyenobu, Johana M. Jarcho, Jim A. McRoberts, Beate Niesler, Emeran A. Mayer 
Gastroenterology 
Volume 140, Issue 7, Pages (June 2011)
DOI: /j.gastro
Copyright © 2011 AGA Institute Terms and Conditions

2. Figure 1
5-HT3R activation on GABAergic interneurons innervating the amygdala exerts an inhibitory influence on amygdala activity, whereas those on excitatory glutaminergic interneurons will exert an excitatory influence.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions

3. Figure 2
(A) The emotional reactivity paradigm activated the amygdala. C/C genotype subjects, regardless of diagnosis, displayed increased amygdala responsiveness during the (B) ME condition and during the (C) MF condition.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions

4. Figure 3
Mean and standard deviation for right amygdala emotional reactivity (defined as βME-MF) is plotted for healthy controls and IBS patients by HTR3A c.-42C>T genotype (C/C vs T carrier). A subset of IBS subjects with C/C genotype had an unusual pattern of amygdala response.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions