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Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers  Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan.

Published byTommi Kouki Modified over 5 years ago

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Presentation on theme: "Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers  Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan."— Presentation transcript:

1 Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers 
Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan Bender, Anatole Ghazalpour, Zheng Tan, Jeffrey Swensen, Sherri Z. Millis, Gargi Basu, Zoran Gatalica, Michael F. Press  The Journal of Molecular Diagnostics  Volume 17, Issue 5, Pages (September 2015) DOI: /j.jmoldx Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 Patient distribution and relative frequency of the HER2 mutations by cancer type and lineage (frequency is only indicated in lineages with more than three mutations detected). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 HER2 mutation spectrum in solid tumors. POS, HER2-positive by HER2 fluorescent in situ hybridization or HER2 overexpression by immunohistochemistry (3+). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

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