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Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging  S. Ishikawa, K. Yokoyama, T. Kuroiwa, K. Makita 

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Presentation on theme: "Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging  S. Ishikawa, K. Yokoyama, T. Kuroiwa, K. Makita "— Presentation transcript:

1 Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging  S. Ishikawa, K. Yokoyama, T. Kuroiwa, K. Makita  British Journal of Anaesthesia  Volume 87, Issue 3, Pages (September 2001) DOI: /bja/ Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 ADC maps, diffusion- and T2-weighted images (DWI and T2WI) on slice A at baseline and 100, 220, and 340 min after thromboembolism. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 ADC maps, diffusion- and T2-weighted images (DWI and T2WI) on slice B at baseline and 100, 220, and 340 min after thromboembolism. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Sequential change in lesion volume. Mean lesion volumes (dashed line) did not differ significantly at the various time points. The lesion volume in individual rats showed some fluctuation during the MRI study (thick lines). British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Percentage change in lesion volume (%ΔLV) at each MRI acquisition interval. The absolute value of %ΔLV at 40–100 min after thomboembolism was two or three times larger than at other intervals. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

6 Fig 5 Correlation analysis between percentage change in lesion volume at 40–100 min after thromboembolism (%ΔLV (T40–100)) and total percentage change in lesion volume (total %ΔLV). There was a significant relationship (r=0.77, P<0.05). British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

7 Fig 6 Sequential changes in mean severe ischaemic lesions in the cortex (•), and caudate putamen (○) on slice A and cortex (▪) and basal ganglia (□) on slice B. Severe ischaemic lesions significantly increased with time in the cortex on both slices. sd are not shown for clarity. *P<0.05, **P<0.01 vs 40 min. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

8 Fig 7 Sequential changes in mean moderate ischaemic lesions in the cortex (•), and caudate putamen (○) on slice A and cortex (▪) and basal ganglia (□) on slice B. There was no significant differences in moderate ischaemic lesions at different time points in any selected region. sd are not shown for clarity. British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

9 Fig 8 Percentage hemispheric infarcted area (%, x) and percentage lesion area on ADC map at 340 min after thromboembolism (%, y). There was a significant correlation on slices A (•, solid line) and B (▪, dashed line). (a) y=1.23x (r=0.88, P<0.01). (b) y=1.00x (r=0.80, P<0.01). British Journal of Anaesthesia  , DOI: ( /bja/ ) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions


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