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Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease  Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,

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Presentation on theme: "Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease  Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,"— Presentation transcript:

1 Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease  Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller, Francine M. Foss  Biology of Blood and Marrow Transplantation  Volume 9, Issue 3, Pages (March 2003) DOI: /S (03) Copyright © 2003 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Fig. 1 Dendritic cell (DC) yield by flow cytometry. DCs were differentiated with GM-CSF and IL-4. Shaded area represents cells stained with DC markers. This figure of a representative patient shows that DCs are predominantly positive for CD80 or CD86. The mean and standard error of measurement (SEM) for DC markers of cultured cells from all 24 patients are shown. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) ) Copyright © 2003 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Fig. 2 Dendritic cell (DC) chimerism following reduced intensity preparative regimen. Chimerism studies were performed on DCs isolated with GM-CSF and IL-4 from peripheral blood mononuclear cells collected on day +100 post-transplant. DNA PCR band pattern for DCs of a patient with no GVHD is all donor. The DC band pattern for a patient with grade II aGVHD and extensive cGVHD was all host. The DC band pattern for a patient who failed engraftment was also all host. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) ) Copyright © 2003 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Fig. 3 Dendritic cell (DC) chimerism following conventional preparative regimen. Chimerism studies were performed on DCs isolated with GM-CSF and IL-4 from peripheral blood mononuclear cells collected on day +100 post-transplant. DNA PCR band pattern for DCs of a patient with no GVHD is all donor. The DC band pattern for a patient with grade IV aGVHD and extensive cGVHD was all host. Biology of Blood and Marrow Transplantation 2003 9, DOI: ( /S (03) ) Copyright © 2003 American Society for Blood and Marrow Transplantation Terms and Conditions

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