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Arresting Cancer Proliferation by Small-Molecule Gene Regulation

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Presentation on theme: "Arresting Cancer Proliferation by Small-Molecule Gene Regulation"— Presentation transcript:

1 Arresting Cancer Proliferation by Small-Molecule Gene Regulation
Liliane A. Dickinson, Ryan Burnett, Christian Melander, Benjamin S. Edelson, Paramjit S. Arora, Peter B. Dervan, Joel M. Gottesfeld  Chemistry & Biology  Volume 13, Issue 3, (March 2006) DOI: /j.chembiol Copyright © 2006 Elsevier Ltd Terms and Conditions

2 Figure 1 Polyamide Conjugate Structure
1R-Chl = ImIm-β-Im-α(R-2,4-DABAChl)-PyPyPyPy-β-Dp, in which Py is pyrrole, Im is imidazole, β is β-alanine, Dp is dimethylaminopropylamine, and 2,4-DABA is (R)-2,4-diaminobutyric acid with α describing the amino acid linking the polyamide and Chl describing the chlorambucil substituent at the 4-amino position. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2006 Elsevier Ltd Terms and Conditions

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