Presentation is loading. Please wait.

Presentation is loading. Please wait.

Expression of Endothelin-1 and Constitutional Nitric Oxide Synthase Messenger RNA in Saphenous Vein Endothelial Cells Exposed to Arterial Flow Shear Stress 

Published byTrond Nesse Modified over 5 years ago

Similar presentations

Presentation on theme: "Expression of Endothelin-1 and Constitutional Nitric Oxide Synthase Messenger RNA in Saphenous Vein Endothelial Cells Exposed to Arterial Flow Shear Stress "— Presentation transcript:

1 Expression of Endothelin-1 and Constitutional Nitric Oxide Synthase Messenger RNA in Saphenous Vein Endothelial Cells Exposed to Arterial Flow Shear Stress  Zhi-Gang Zhu, MD, PhD, Hui-Hua Li, MD, Bao-Ren Zhang, MD  The Annals of Thoracic Surgery  Volume 64, Issue 5, Pages (November 1997) DOI: /S (97)00859-X Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Expression of constitutional nitric oxide synthase (cNOS) messenger RNA (mRNA) by cultured human saphenous vein cells under different flow shear stresses. At 7 hours, compared with group III, the expression levels of cNOS mRNA (expressed as mean value) were significantly decreased in group I (p<0.001) and group IV (p<0.05) but were increased in group II (p<0.05). After 24 hours, cNOS mRNA expression had no significant changes in groups II, III, and IV but was significantly decreased in group I (p<0.05) as compared with the expression at 7 hours. (Group I, 30 dynes/cm2; group II, 6 dynes/cm2; group III, 2 dynes/cm2; group IV, 0 dynes/cm2.) (RND = relative densitometric ratio of cNOS mRNA expression against glyceraldehyde-3-phosphate dehydrogenase mRNA expression.) The Annals of Thoracic Surgery  , DOI: ( /S (97)00859-X) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Expression of endothelin-1 (ET-1) messenger RNA (mRNA) by cultured human saphenous vein cells under different flow shear stresses. At 7 hours, compared with group III, the expression levels of ET-1 mRNA (expressed as mean value) were significantly increased in group I (p<0.01) and group IV (p<0.01) but were decreased in group II (p<0.05). After 24 hours, ET-1 mRNA expression had no significant changes in groups II, III, and IV but was significantly increased in group I (p<0.05) as compared with the expression at 7 hours. (Group I, 30 dynes/cm2; group II, 6 dynes/cm2; group III, 2 dynes/cm2; group IV, 0 dynes/cm2.) (RND = relative densitometric ratio of ET-1 mRNA expression against glyceral-dehyde-3-phosphate dehydrogenase mRNA expression.) The Annals of Thoracic Surgery  , DOI: ( /S (97)00859-X) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Download ppt "Expression of Endothelin-1 and Constitutional Nitric Oxide Synthase Messenger RNA in Saphenous Vein Endothelial Cells Exposed to Arterial Flow Shear Stress "

Similar presentations

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix Sarah E. Gilpin, PhD, Xi Ren, PhD, Tatsuya.

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix Sarah E. Gilpin, PhD, Xi Ren, PhD, Tatsuya.
Perioperative Statin Therapy for Patients Undergoing Coronary Artery Bypass Grafting  Amr F. Barakat, MD, Marwan Saad, MD, PhD, Ahmed Abuzaid, MD, Amgad.

Perioperative Statin Therapy for Patients Undergoing Coronary Artery Bypass Grafting  Amr F. Barakat, MD, Marwan Saad, MD, PhD, Ahmed Abuzaid, MD, Amgad.
Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells  Anthony G. Passerini, PhDa,

Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells  Anthony G. Passerini, PhDa,
Effusive Tuberculous Pericarditis

Effusive Tuberculous Pericarditis
Perioperative Statin Therapy for Patients Undergoing Coronary Artery Bypass Grafting  Amr F. Barakat, MD, Marwan Saad, MD, PhD, Ahmed Abuzaid, MD, Amgad.

Perioperative Statin Therapy for Patients Undergoing Coronary Artery Bypass Grafting  Amr F. Barakat, MD, Marwan Saad, MD, PhD, Ahmed Abuzaid, MD, Amgad.
Wei Zhou, MD, Hong Chai, MD, PhD, Andy Courson, BS, Peter H

Wei Zhou, MD, Hong Chai, MD, PhD, Andy Courson, BS, Peter H
Bone Morphogenic Protein-4 Contributes to Venous Endothelial Dysfunction in Patients With Diabetes Undergoing Coronary Revascularization  Jia Hu, MD,

Bone Morphogenic Protein-4 Contributes to Venous Endothelial Dysfunction in Patients With Diabetes Undergoing Coronary Revascularization  Jia Hu, MD,
Homograft Aortic Replacement for Infected Mediastinal False Aneurysm

Homograft Aortic Replacement for Infected Mediastinal False Aneurysm
Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia- Reperfusion Injury in Diabetic Rats  Juchen Li, MD, Yixing Ren, MD,

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia- Reperfusion Injury in Diabetic Rats  Juchen Li, MD, Yixing Ren, MD,
Vein Graft Harvesting Induces Inflammation and Impairs Vessel Reactivity  Kazuhiro Hinokiyama, MD, Guro Valen, MD, PhD, Shinichi Tokuno, MD, PhD, Jenny.

Vein Graft Harvesting Induces Inflammation and Impairs Vessel Reactivity  Kazuhiro Hinokiyama, MD, Guro Valen, MD, PhD, Shinichi Tokuno, MD, PhD, Jenny.
Thomas V Bilfinger, MD, George B Stefano, PhD 

Thomas V Bilfinger, MD, George B Stefano, PhD 
Clinical and Potential Use of Pharmacological Agents to Reduce Radial Artery Spasm in Coronary Artery Surgery  Saina Attaran, MD, Lindsay John, MD, Ahmed.

Clinical and Potential Use of Pharmacological Agents to Reduce Radial Artery Spasm in Coronary Artery Surgery  Saina Attaran, MD, Lindsay John, MD, Ahmed.
The Annals of Thoracic Surgery

The Annals of Thoracic Surgery
Lung Cancer Staging: A Case for a New T Definition

Lung Cancer Staging: A Case for a New T Definition
Evidence of Nitric Oxide Produced by the Internal Mammary Artery Graft in Venous Drainage of the Recipient Coronary Artery  Ferenc I. Tarr, MD, PhD, Mária.

Evidence of Nitric Oxide Produced by the Internal Mammary Artery Graft in Venous Drainage of the Recipient Coronary Artery  Ferenc I. Tarr, MD, PhD, Mária.
Right internal thoracic artery or saphenous vein grafting

Right internal thoracic artery or saphenous vein grafting
High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,

High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer  Shu-Mei Yan, MD, Hui-Ni Wu, MB, Fan He, MD,
The Society of Thoracic Surgeons Thoracic Surgery Practice and Access Task Force: 2014 Workforce Report  John S. Ikonomidis, MD, PhD  The Annals of Thoracic.

The Society of Thoracic Surgeons Thoracic Surgery Practice and Access Task Force: 2014 Workforce Report  John S. Ikonomidis, MD, PhD  The Annals of Thoracic.
Daniel J. Wong, MD, Daniel Y. Lu, MD, Clinton D

Daniel J. Wong, MD, Daniel Y. Lu, MD, Clinton D
Lindsay C.H. John, MD, FRCS  The Annals of Thoracic Surgery 

Lindsay C.H. John, MD, FRCS  The Annals of Thoracic Surgery 

Similar presentations

Ads by Google