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Figure 1 The human adaptive immune profile in multiple sclerosis (MS)‏

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Presentation on theme: "Figure 1 The human adaptive immune profile in multiple sclerosis (MS)‏"— Presentation transcript:

1 Figure 1 The human adaptive immune profile in multiple sclerosis (MS)‏
The human adaptive immune profile in multiple sclerosis (MS) In A and B, the right upper half, above the diagonal, indicates coregulation between pairs of cell types in healthy controls (n = 36) (red: positive correlation coefficient, blue: negative correlation coefficient, light gray: no data available). Unbiased clustering of coefficients was performed to group coregulated cell types. Upon clustering, a main distinct naive cluster was observed, consisting of coregulated CD4+ T cells, CD4+/CD8+ ratio, and naive T cells, together with recent thymic emigrants (RTE) of both CD4+ and CD8+ lineages. This naive cluster was negatively correlated with activated and antigen-experienced lymphocyte subsets. Several microclusters were additionally observed, with coregulation of regulatory T cells (Tregs) with central memory CD4+ and CD8+ T cells (the antigen-experienced microcluster), coregulation of Th1 cells and interferon-γ-producing CD8+ cells (the Th1 microcluster), coregulation of Th2 and memory B cells (the Th2 microcluster), and so forth, revealing the emergence of known immunologic interactions through this systems immunology approach. In the lower left half, below the diagonal, dark gray indicates coregulation between pairs of cell types in (A) patients with untreated MS (MS_UNT, n = 56) and (B) patients with autoimmune thyroid disease (AITD, n = 55) that does not differ significantly from healthy controls. Coregulation between pairs of cell types that is significantly altered by disease (p < 0.05, and boxed if p < 0.01) in (A) untreated patients with MS vs controls and (B) patients with AITD vs controls is colored (red: positive correlation coefficient, blue: negative correlation coefficient, light gray: no data available). James Dooley et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e240 © 2016 American Academy of Neurology

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Date of download: 7/10/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Altered CD4+/CD8+ T-Cell Ratios in Cerebrospinal.

Date of download: 7/10/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Altered CD4+/CD8+ T-Cell Ratios in Cerebrospinal.
Figure 2 ERG amplitude reduction in the follow-up study

Figure 2 ERG amplitude reduction in the follow-up study
Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.

Figure 2 Orbital MRI findings One-third of myelin oligodendrocyte glycoprotein antibody–positive patients revealed extensive enhancement patterns that.
Figure 3 Antibodies to MOG using different secondary antibodies: Anti-human IgG (H + L), IgG1, or IgM(A) Comparison of binding to full-length myelin oligodendrocyte.

Figure 3 Antibodies to MOG using different secondary antibodies: Anti-human IgG (H + L), IgG1, or IgM(A) Comparison of binding to full-length myelin oligodendrocyte.
Figure 4 Relation of neuropsychological deficits and intrathecal immune cell subsets in GABAB receptor antibody–associated limbic encephalitis Relation.

Figure 4 Relation of neuropsychological deficits and intrathecal immune cell subsets in GABAB receptor antibody–associated limbic encephalitis Relation.
Figure 5 Treatment with fingolimod raises the activation threshold of monocytes in MS Peripheral blood mononuclear cells from 8 healthy donors, 7 patients.

Figure 5 Treatment with fingolimod raises the activation threshold of monocytes in MS Peripheral blood mononuclear cells from 8 healthy donors, 7 patients.
Figure 3 Differentiation and functional control of T-cell subsets

Figure 3 Differentiation and functional control of T-cell subsets
Figure 3 JCV index changes in JCV+ patients

Figure 3 JCV index changes in JCV+ patients
Figure 2 Comparative milestones in T and B lymphocyte maturation

Figure 2 Comparative milestones in T and B lymphocyte maturation
Figure 1 Neuromyelitis optica spectrum disorder (NMOSD) subgroups and patients with relapsing-remitting multiple sclerosis (RRMS) show different antibody.

Figure 1 Neuromyelitis optica spectrum disorder (NMOSD) subgroups and patients with relapsing-remitting multiple sclerosis (RRMS) show different antibody.
Figure 2 Brain-infiltrating immune cells mainly consist of CD8+ memory T cells Immunofluorescence staining of brain-infiltrating immune cells. Brain-infiltrating.

Figure 2 Brain-infiltrating immune cells mainly consist of CD8+ memory T cells Immunofluorescence staining of brain-infiltrating immune cells. Brain-infiltrating.
Figure 1 Effect of DMF therapy on T cell subsets

Figure 1 Effect of DMF therapy on T cell subsets
Figure 2 Alemtuzumab-induced changes in the dendritic cell compartment

Figure 2 Alemtuzumab-induced changes in the dendritic cell compartment
Figure 1 The abundance of CD3+ T cells and their subtypes are significantly affected by FTY and DMF treatment The abundance of CD3+ T cells and their subtypes.

Figure 1 The abundance of CD3+ T cells and their subtypes are significantly affected by FTY and DMF treatment The abundance of CD3+ T cells and their subtypes.
Figure 1 MOR103 sequential-dose trial flowchart of study population with multiple sclerosis aPatients received 2 doses of study drug before trial withdrawal.

Figure 1 MOR103 sequential-dose trial flowchart of study population with multiple sclerosis aPatients received 2 doses of study drug before trial withdrawal.
Figure 1 8-Iso-PGF2α levels in CSF of patients with MS and controlsCSF 8-iso-prostaglandin F2α (8-iso-PGF2α) levels were estimated using an ELISA. (A)

Figure 1 8-Iso-PGF2α levels in CSF of patients with MS and controlsCSF 8-iso-prostaglandin F2α (8-iso-PGF2α) levels were estimated using an ELISA. (A)
Figure 1 Peripheral blood leukocyte subset counts during dimethyl fumarate treatmentComplete blood cell counts were obtained at baseline (n = 34) and at.

Figure 1 Peripheral blood leukocyte subset counts during dimethyl fumarate treatmentComplete blood cell counts were obtained at baseline (n = 34) and at.
Figure 3 Effects of RTX on specific anti-pathogen IgGs

Figure 3 Effects of RTX on specific anti-pathogen IgGs
Figure 2. ROC curves for different group comparisons

Figure 2. ROC curves for different group comparisons
Figure 2 JCV index JCV index (A) Fifty samples of natalizumab-treated patients with multiple sclerosis were assessed twice for their anti-JCV antibody.

Figure 2 JCV index JCV index (A) Fifty samples of natalizumab-treated patients with multiple sclerosis were assessed twice for their anti-JCV antibody.

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