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A Novel Cytidine Deaminase Affects Antibody Diversity

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Presentation on theme: "A Novel Cytidine Deaminase Affects Antibody Diversity"— Presentation transcript:

1 A Novel Cytidine Deaminase Affects Antibody Diversity
Angelika Longacre, Ursula Storb  Cell  Volume 102, Issue 5, Pages (September 2000) DOI: /S (00)

2 Figure 1 Ig Gene Class Switch Recombination
Example of switching from Cμ to Cε. S, switch region; the flags indicate transcription promoters. Cell  , DOI: ( /S (00) )

3 Figure 2 Distribution of Mutations in Somatic Hypermutation of Ig Genes Cell  , DOI: ( /S (00) )

4 Figure 3 Model of Somatic Hypermutation of Ig Genes
E, Ig enhancer; IEB, Ig enhancer binding proteins; MuF, mutator factor; pol, RNA polymerase; Fen1, flap endonuclease 1; x, mutation. Cell  , DOI: ( /S (00) )


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