1. Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study 
Daniel B Hawcutt, MD, Ben Francis, PhD, Daniel F Carr, PhD, Andrea L Jorgensen, PhD, Peng Yin, PhD, Naomi Wallin, BN, Natalie O'Hara, BSc, Eunice J Zhang, PhD, Katarzyna M Bloch, PhD, Amitava Ganguli, MRCP, Ben Thompson, MBChB, Laurence McEvoy, BSc, Prof Matthew Peak, PhD, Andrew A Crawford, PhD, Prof Brian R Walker, MD, Joanne C Blair, MD, Jonathan Couriel, MA, Prof Rosalind L Smyth, FMedSci, Prof Munir Pirmohamed, FMedSci 
The Lancet Respiratory Medicine 
Volume 6, Issue 6, Pages (June 2018)
DOI: /S (18)
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

2. Figure 1
Manhattan (A) and Q-Q (B) plots of genome-wide data relating to dichotomous outcome of peak cortisol less than 350 nmol/L
Data obtained by undertaking a low-dose short synacthen test in all participants. (A) Blue line represents the notional statistical significance threshold; red line represents the genome-wide statistical significance threshold. (B) Red diagonal line is the unity line indicating the quintiles of the p values come from the same distribution.
The Lancet Respiratory Medicine 2018 6, DOI: ( /S (18) )
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

3. Figure 2
Manhattan (A) and Q-Q (B) plots of genome-wide data relating to dichotomous outcome of peak cortisol less than 500 nmol/L
Data obtained by undertaking a low-dose short synacthen test in all participants. (A) Blue line represents the notional statistical significance threshold. (B) Red diagonal line is the unity line indicating the quintiles of the p values come from the same distribution.
The Lancet Respiratory Medicine 2018 6, DOI: ( /S (18) )
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

4. Figure 3
Manhattan (A) and Q-Q (B) plots of genome-wide data relating to continuous outcome of peak cortisol levels
Data obtained by undertaking a low-dose short synacthen test in all participants. (A) Blue line represents the notional statistical significance threshold; red line represents the genome-wide statistical significance threshold. (B) Red diagonal line is the unity line indicating the quintiles of the p values come from the same distribution.
The Lancet Respiratory Medicine 2018 6, DOI: ( /S (18) )
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

5. Figure 4
Manhattan (A) and Q-Q (B) plots of genome-wide data relating to continuous outcome of baseline (log-transformed) cortisol levels
Data obtained by undertaking a low-dose short synacthen test in all participants. (A) Blue line represents the notional statistical significance threshold; red line represents the genome-wide statistical significance threshold. (B) Red diagonal line is the unity line indicating the quintiles of the p values come from the same distribution.
The Lancet Respiratory Medicine 2018 6, DOI: ( /S (18) )
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

6. Figure 5
Meta-analysis of (A) all children with asthma treated with corticosteroids and (B) all children with asthma and adults with COPD
OR=odds ratio.
The Lancet Respiratory Medicine 2018 6, DOI: ( /S (18) )
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions