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Augmented epithelial endothelin-1 expression in refractory asthma

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Presentation on theme: "Augmented epithelial endothelin-1 expression in refractory asthma"— Presentation transcript:

1 Augmented epithelial endothelin-1 expression in refractory asthma
Sophie Pégorier, PhD, Nassim Arouche, MSc, Marie-Christine Dombret, MD, Michel Aubier, MD, Marina Pretolani, PhD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 6, Pages (December 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Representative immunostaining of EDN1 in bronchial biopsy specimens from control subjects (A), a patient with mild steroid-untreated asthma (B), and patients with severe steroid-sensitive (C) and steroid-refractory (D) asthma is shown. Scale bars = 250 μm. E, proportion of EDN1-positive epithelial cells per millimeter of SBM in bronchial biopsy specimens from control subjects and the 3 groups of asthmatic patients. Bars represent median values, and error bars denote interquartile ranges. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Epithelial integrity (A), SBM thickness (B), and ASM areas (C) in bronchial biopsy specimens from control subjects and asthmatic patients are shown. Bars represent median values, and error bars denote interquartile ranges. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Representative immunostaining of fibroblasts and myofibroblasts (propyl-4-hydroxylase–positive cells) in bronchial biopsy specimens from a control subject (A), a patient with mild steroid-untreated asthma (B), and patients with severe steroid-sensitive (C) and refractory (D) asthma is shown. Scale bars = 250 μm. E, Numbers of fibroblasts/myofibroblasts per millimeter of SBM in bronchial biopsy specimens from control subjects and the 3 groups of asthmatic patients. Bars represent median values, and error bars denote interquartile ranges. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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