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Pretransplant Neutropenia Is Associated with Poor-Risk Cytogenetic Features and Increased Infection-Related Mortality in Patients with Myelodysplastic.

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Presentation on theme: "Pretransplant Neutropenia Is Associated with Poor-Risk Cytogenetic Features and Increased Infection-Related Mortality in Patients with Myelodysplastic."— Presentation transcript:

1 Pretransplant Neutropenia Is Associated with Poor-Risk Cytogenetic Features and Increased Infection-Related Mortality in Patients with Myelodysplastic Syndromes  Bart L. Scott, J.Y. Park, H. Joachim Deeg, Kieren A. Marr, Michael Boeckh, Thomas R. Chauncey, Frederick R. Appelbaum, Rainer Storb, Barry E. Storer  Biology of Blood and Marrow Transplantation  Volume 14, Issue 7, Pages (July 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 OS among neutropenic (ANC <1500/μL) and nonneutropenic (ANC ≥1500/μL) patients. HR = 1.55 ( ), P = .007. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 NRM among neutropenic and nonneutropenic patients. HR = 1.62 ( ), P = .01. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Infection-related mortality among neutropenic and nonneutropenic patients. HR = 2.22 ( ), P = .01. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 (A) Percent of invasive fungal infections among neutropenic and nonneutropenic patients from day 0 to day 100 posttransplant. HR = 2.89 ( ), P = .01. (B) Percent of Gram-positive bacterial infections among neutropenic and nonneutropenic patients from day 0 to day 100 posttransplant. HR = 1.77 ( ), P = .02. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions


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