Presentation is loading. Please wait.

Presentation is loading. Please wait.

Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness  Yoko Yamaguchi,

Published byBranden McKenzie Modified over 5 years ago

Similar presentations

Presentation on theme: "Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness  Yoko Yamaguchi,"— Presentation transcript:

1 Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness  Yoko Yamaguchi, MD, Genichiro Ishii, MD, Motohiro Kojima, MD, Kiyotaka Yoh, MD, Hajime Otsuka, MD, Yoichi Otaki, MD, Keiju Aokage, MD, Shingo Yanagi, Kanji Nagai, MD, Yutaka Nishiwaki, MD, Atsushi Ochiai, MD  Journal of Thoracic Oncology  Volume 5, Issue 9, Pages (September 2010) DOI: /JTO.0b013e3181eaf2f3 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Histologic features of tumor budding. A, Tumor budding in the area of fibrosis (hematoxylin and eosin [HE] staining). B, Moderate magnification of the area boxed in A: budding cells (BCs) are observed in the fibrotic stroma (HE staining). C, Higher magnification of the area boxed in A. Tumor budding is visible in the form of isolated small clusters or single invading carcinoma cells with eosinophilic cytoplasm (HE staining). D, Cytokeratin AE1/3 immunostaining of BCs. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181eaf2f3) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Cumulative overall survival curves. A, Cumulative overall survival curves of 181 patients stratified by the presence or absence of tumor budding. B, Cumulative overall survival curves of 181 patients stratified by grade of tumor budding. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181eaf2f3) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Differences in the immunostaining for β-catenin, E-cadherin, laminin-5γ2, and SP-A. A, β-catenin staining: decreased membrane immunostaining was found in BC (arrows) compared with tumor cells forming solid nests. B, E-cadherin staining: decreased membrane immunostaining was found in BC (arrows) compared with tumor cells forming solid nests. C, Laminin-5γ2 staining: increased cytoplasm immunostaining was found in BC (arrows) compared with tumor cells forming solid nests. D, SP-A staining: decreased cytoplasm immunostaining was found in BC (arrows) compared with tumor cells forming solid nests. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181eaf2f3) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

Download ppt "Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness  Yoko Yamaguchi,"

Similar presentations

Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma  Hideyuki Imoto, MD, Toshihiro.

Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma  Hideyuki Imoto, MD, Toshihiro.
Primary Signet-Ring Carcinoma (SRC) of the Lung: A Population-Based Epidemiologic Study of 262 Cases with Comparison to Adenocarcinoma of the Lung  Sai-Hong.

Primary Signet-Ring Carcinoma (SRC) of the Lung: A Population-Based Epidemiologic Study of 262 Cases with Comparison to Adenocarcinoma of the Lung  Sai-Hong.
Clinical Outcome of Chemoradiation Therapy in Patients with Limited-Disease Small Cell Lung Cancer with Ipsilateral Pleural Effusion  Seiji Niho, MD,

Clinical Outcome of Chemoradiation Therapy in Patients with Limited-Disease Small Cell Lung Cancer with Ipsilateral Pleural Effusion  Seiji Niho, MD,
Primary Mucoepidermoid Carcinoma of the Esophagus

Primary Mucoepidermoid Carcinoma of the Esophagus
Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.

Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.
Histopathologic Prognostic Factors in Resected Colorectal Lung Metastases  Satoshi Shiono, MD, Genichiro Ishii, MD, Kanji Nagai, MD, Junji Yoshida, MD,

Histopathologic Prognostic Factors in Resected Colorectal Lung Metastases  Satoshi Shiono, MD, Genichiro Ishii, MD, Kanji Nagai, MD, Junji Yoshida, MD,
Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.
Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.

Malignant Pleural Mesothelioma Harboring Both G719C and S768I Mutations of EGFR Successfully Treated with Afatinib  Nobukazu Agatsuma, MD  Journal of.
Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.

Prognostic Significance of the Number of Lymph Nodes Removed at Lobectomy in Stage IA Non-small Cell Lung Cancer  Sai-Hong Ignatius Ou, MD, PhD, Jason.
E-cadherin expression associated with differentiation and prognosis in patients with non–small cell lung cancer  Dage Liu, MD, Cheng-long Huang, MD, Kotaro.

E-cadherin expression associated with differentiation and prognosis in patients with non–small cell lung cancer  Dage Liu, MD, Cheng-long Huang, MD, Kotaro.
A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.

A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.
Y-L Chang, MD, C-T Wu, MD, Y-C Lee, MD, PhD 

Y-L Chang, MD, C-T Wu, MD, Y-C Lee, MD, PhD 
Long-Term Survival in Two Cases of Resected Gastric Metastasis of Pulmonary Pleomorphic Carcinoma  Keiju Aokage, MD, Junji Yoshida, MD, Genichiro Ishii,

Long-Term Survival in Two Cases of Resected Gastric Metastasis of Pulmonary Pleomorphic Carcinoma  Keiju Aokage, MD, Junji Yoshida, MD, Genichiro Ishii,
Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,
APLCC ORAL ABSTRACT SESSIONS - MONDAY, NOVEMBER 26

APLCC ORAL ABSTRACT SESSIONS - MONDAY, NOVEMBER 26
Bronchioloalveolar Carcinoma (Lepidic Growth) Component Is a More Useful Prognostic Factor than Lymph Node Metastasis  Yoichi Anami, MD, Tatsuo Iijima,

Bronchioloalveolar Carcinoma (Lepidic Growth) Component Is a More Useful Prognostic Factor than Lymph Node Metastasis  Yoichi Anami, MD, Tatsuo Iijima,
The impact on survival of positive intraoperative pleural lavage cytology in patients with non–small-cell lung cancer  Keiju Aokage, MD, Junji Yoshida,

The impact on survival of positive intraoperative pleural lavage cytology in patients with non–small-cell lung cancer  Keiju Aokage, MD, Junji Yoshida,
Nicolas Girard, MD, Julie Teruya-Feldstein, MD, Eden C

Nicolas Girard, MD, Julie Teruya-Feldstein, MD, Eden C
Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting.

Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting.
Therapeutic Priority of the PI3K/AKT/mTOR Pathway in Small Cell Lung Cancers as Revealed by a Comprehensive Genomic Analysis  Shigeki Umemura, MD, PhD,

Therapeutic Priority of the PI3K/AKT/mTOR Pathway in Small Cell Lung Cancers as Revealed by a Comprehensive Genomic Analysis  Shigeki Umemura, MD, PhD,

Similar presentations

Ads by Google