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Reversibility of Blue-Gray Cutaneous Discoloration From Amiodarone

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1 Reversibility of Blue-Gray Cutaneous Discoloration From Amiodarone
JOSEPH L. BLACKSHEAR, M.D.  Mayo Clinic Proceedings  Volume 66, Issue 7, Pages (July 1991) DOI: /S (12) Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Fig. 1 A and B, Frontal and lateral facial photographs (taken on Sept. 28, 1988) of patient with amiodarone-induced cutaneous discoloration. The patient had taken 600 mg of amiodarone daily since January C and D, Subsequent frontal and lateral facial photographs (taken on Apr. 6, 1990) of same patient. Amiodarone therapy had been discontinued in September 1988. Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Fig. 2 Biopsy specimens of forearm skin (obtained on Nov. 7, 1988) from patient with amiodarone-induced cutaneous discoloration (shown in Figure 1). A, Intracellular and free pigment was noted at dermal-epidermal junction and in dermis. (Hematoxylin-eosin; original magnification ×400.) B, Melanin stain (Fontana-Masson silver method) indicated that most of the melanin was in basal layer. (Original magnification; ×100.) Mayo Clinic Proceedings  , DOI: ( /S (12) ) Copyright © 1991 Mayo Foundation for Medical Education and Research Terms and Conditions


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