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HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy
Qingqing Wei, Zheng Dong Kidney International Volume 86, Issue 4, Pages (October 2014) DOI: /ki Copyright © 2014 International Society of Nephrology Terms and Conditions
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Figure 1 Schematic diagram of HDAC4–STAT1 pathway in podocyte injury. HDAC4 interacts with and deacetylates STAT1 to promote the phosphorylation and activation of STAT1, which then translocates into the nucleus to induce gene expression, leading to the induction of inflammation and apoptosis and the suppression of autophagy. Kidney International , DOI: ( /ki ) Copyright © 2014 International Society of Nephrology Terms and Conditions
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