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Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview  F.W.

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Presentation on theme: "Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview  F.W."— Presentation transcript:

1 Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview  F.W. Roemer, C. Miller, K. Hoover, C. Hayes, C. West, M. Brown, R. Clemmer, A. Guermazi  Osteoarthritis and Cartilage  Volume 23, Pages A359-A360 (April 2015) DOI: /j.joca Copyright © Terms and Conditions

2 Fig 1A Baseline radiograph shows a normal medial and lateral joint space width. Osteoarthritis and Cartilage  , A359-A360DOI: ( /j.joca ) Copyright © Terms and Conditions

3 Fig1B. 6 months follow-up radiograph depicts definite medial joint space narrowing (JSN; arrows) with persistent absence of osteophytes medially consistent with RPOA. Osteoarthritis and Cartilage  , A359-A360DOI: ( /j.joca ) Copyright © Terms and Conditions

4 Fig 2. Coronal T1 weighted MR image shows typical metaphyseal osteonecrosis (arrows) with central fat-like signal (asterisk). Osteoarthritis and Cartilage  , A359-A360DOI: ( /j.joca ) Copyright © Terms and Conditions

5 Fig 3A Radiograph of the hip joint shows superior JSN (arrows) without relevant osteophytes present. Osteoarthritis and Cartilage  , A359-A360DOI: ( /j.joca ) Copyright © Terms and Conditions

6 Fig 3B Follow up image 12 months later shows near-complete destruction of the femoral head (arrows) and subsequent migration of the femur superiorly consistent with RPOA. Osteoarthritis and Cartilage  , A359-A360DOI: ( /j.joca ) Copyright © Terms and Conditions


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