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A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life

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Presentation on theme: "A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life"— Presentation transcript:

1 A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life
Yi Zhou, Tinglin Lu, Ting Xie  Cell Metabolism  Volume 14, Issue 5, Pages (November 2011) DOI: /j.cmet Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 A Working Model Explaining How dPGC-1 Might Regulate ISC Aging and Organismal Aging as Demonstrated in the Study by Rera et al dPGC-1 overexpression in intestinal stem cells (ISC) and immediate progenitor cells enteroblasts (EB) leads to an increase in mitochondrial activity and a decrease in intracellular ROS levels throughout the intestinal epithelium. dPGC1 overexpression prevents age-related loss of intestinal homeostasis and integrity and promotes longevity in Drosophila. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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