1. Analysis of the Biliary Transcriptome in Experimental Biliary Atresia
Elisa Carvalho, Cong Liu, Pranavkumar Shivakumar, Gregg Sabla, Bruce Aronow, Jorge A. Bezerra 
Gastroenterology 
Volume 129, Issue 2, Pages (August 2005)
DOI: /j.gastro
Copyright © 2005 American Gastroenterological Association Terms and Conditions

2. Figure 1
(A) Data filtering and 2-way hierarchic cluster analysis of the biliary transcriptome identify 359 genes that differ at least 2-fold in rotavirus (RV)-challenged mice when compared with normal saline (NS) controls. The levels of gene expression are depicted as color variation from red (high expression) to green (low expression); each column represents the data from a microarray hybridized with a complementary RNA pool from 2–3 mice. (B) Number of genes from A that are up-regulated in RV mice above NS controls, and grouped into specific biological functions at 3, 7, and 14 days after RV or NS injection.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

3. Figure 2
Histologic cross-sections of the extrahepatic bile duct after rotavirus (RV) challenge showing mild inflammatory cell infiltration at 3 days, and pronounced cholangitis and injury to duct epithelium (arrows) at 7 days (also see Supplementary Figure 1). The histologic abnormalities are associated with the temporal expression of a hierarchic network of IFN responsive factors (Irf7 and Irf9), followed by IFN-γ and IFN-γ–regulated genes. The increased levels of expression for these genes were validated by real-time polymerase chain reaction (Supplementary Table 4). Black bar, 100 μm.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions