1. Optimal Treatment of PAH

2. Endothelial Dysfunction in PAH

3. Treatment Algorithm for PAH

4. Recommendations for General Measures

5. Recommendations for Supportive Therapy

6. Treatment Algorithm for PAH

7. Risk Assessment in PAH

8. Treatment Algorithm for PAH

9. Monotherapy Recommendations for PAH

10. Initial Combination Therapy Recommendations for PAH

11. Sequential Combination Therapy Recommendations for PAH

12. The Rationale for Combination Therapy

13. Expert Consensus Recommendations for Combination Therapy Have Improved With Increasing Experience

14. An Evolving Paradigm From Sequential to Initial Upfront Combination Therapy

15. AMBITION Study Design

16. AMBITION Results

17. Initial Dual Oral Combination Therapy for PAH Experience of the French Network

18. Initial Dual Oral Combination Therapy for PAH Experience of the French Network

19. Selexipag

20. GRIPHON Selexipag for the Treatment of PAH

21. GRIPHON Primary End Point

22. Looking Forward

23. Abbreviations

24. Abbreviations (cont)

25. Abbreviations (cont)

26. References

27. References (cont)

28. References (cont)