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Gas chromatograph–surface acoustic wave for quick real-time assessment of blood/exhaled gas ratio of propofol in humans  X. Chen, X.L. Zhang, L. Liu,

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Presentation on theme: "Gas chromatograph–surface acoustic wave for quick real-time assessment of blood/exhaled gas ratio of propofol in humans  X. Chen, X.L. Zhang, L. Liu,"— Presentation transcript:

1 Gas chromatograph–surface acoustic wave for quick real-time assessment of blood/exhaled gas ratio of propofol in humans  X. Chen, X.L. Zhang, L. Liu, Y. Chen, M.Y. Piao, F.J. Zhang, W.D. Wu, Y.B. Zhong, K. Sun, Y.C. Zou, X. Zhang, D. Wang, P. Wang, M. Yan  British Journal of Anaesthesia  Volume 113, Issue 5, Pages (November 2014) DOI: /bja/aeu193 Copyright © 2014 The Author(s) Terms and Conditions

2 Fig 1 Structure of the fast GC–SAW detection system.
British Journal of Anaesthesia  , DOI: ( /bja/aeu193) Copyright © 2014 The Author(s) Terms and Conditions

3 Fig 2 Calibrations of GC–SAW by different propofol concentrations in gas phase (24, 48, 72, 96, 120, and 240 pg ml−1, 1 ppb corresponds to ∼8 pg ml−1 at room temperature): (a) detection spectra of different propofol concentrations in gas phase; (b) linear correlation between responses of SAW sensor and propofol concentrations in gas phase. British Journal of Anaesthesia  , DOI: ( /bja/aeu193) Copyright © 2014 The Author(s) Terms and Conditions

4 Fig 3 Calibrations of GC–SAW by different propofol concentrations (0.5, 1, 2, 3, and 4 μg ml−1) in spiked blood samples: (a) detection spectra of spiked blood samples from a healthy volunteer; (b) linear correlation between responses of SAW sensor and propofol concentrations in spiked blood samples in six healthy volunteers. British Journal of Anaesthesia  , DOI: ( /bja/aeu193) Copyright © 2014 The Author(s) Terms and Conditions

5 Fig 4 Results of simultaneous determination of propofol concentrations in blood and those in exhaled gas by GC–SAW: (a) SAW responses (with the best fitted PK model) to the propofol concentrations in the HS of blood and those in exhaled gas of a patient after a bolus injection of propofol; (b) linear correlation between simulated SAW responses to the concentrations in the HS of blood and those in exhaled gas; the 150 joint points of simulated SAW responses were, respectively, from the best fitted PK model of blood and that of exhaled gas and the slope was considered as RBE; (c) propofol concentrations (μg ml−1) in blood (with the best fitted PK model) and those (pg ml−1) in exhaled gas of a patient after a bolus injection of propofol; (d) linear correlation between simulated propofol concentrations in blood and those in exhaled gas; the 150 joint points of simulated propofol concentrations were, respectively, from the best fitted PK model of blood and that of exhaled gas and the slope was considered as BEGPC. British Journal of Anaesthesia  , DOI: ( /bja/aeu193) Copyright © 2014 The Author(s) Terms and Conditions

6 Fig 5 Distributions of the partial pressure ratio RBE and BEGPC for (a and c) all patients and (b and d) for patients with a correlation coefficient of R L 2 > 0.9 . British Journal of Anaesthesia  , DOI: ( /bja/aeu193) Copyright © 2014 The Author(s) Terms and Conditions


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