1. The Dark Side of Cyclophosphamide: Cyclophosphamide-Mediated Ablation of Regulatory T Cells 
Jürgen C. Becker, David Schrama 
Journal of Investigative Dermatology 
Volume 133, Issue 6, Pages (June 2013)
DOI: /jid
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2. Figure 1
Tumor-inhibiting or -promoting microenvironment. Dependent on the cellular composition of the microenvironment, tumor growth can be inhibited (left side) or promoted (right side). Among N, M, and Th cells, a type 1 or type 2 can be distinguished. CTL, cytotoxic T cell; M, macrophages; MDSC, myeloid-derived suppressor cell; N, neutrophils; Th, helper T cell; Treg, regulatory T cell.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Cyclophosphamide can inhibit regulatory T cells but at the same time induce myeloid-derived suppressor cells. Cytotoxic T cells (CTLs), NK cells, and CD4 cells can mediate the killing of tumor cells (right side). Regulatory T cells (Tregs) can inhibit the activity of CTL and CD4 T cells. Myeloid-derived suppressor cells (MDSCs) are able to stimulate Tregs, and to interact with tumor cells leading to proliferation, survival, and growth of the tumor cells. TGF, transforming growth factor.
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Journal of Investigative Dermatology 2013 133, 1462-1465DOI: (10
Journal of Investigative Dermatology  , DOI: ( /jid )
Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions