1. InterVar: Clinical Interpretation of Genetic Variants by the 2015 ACMG-AMP Guidelines 
Quan Li, Kai Wang 
The American Journal of Human Genetics 
Volume 100, Issue 2, Pages (February 2017)
DOI: /j.ajhg
Copyright © 2017 American Society of Human Genetics Terms and Conditions

2. Figure 1 Flowchart of the Two-Step Procedure of InterVar
Underlined and bold fonts denote automated criteria.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2017 American Society of Human Genetics Terms and Conditions

3. Figure 2
Illustration of the 28 Criteria from the 2015 ACMG-AMP Guidelines
For some criteria, the name of the internal database and its size are denoted within parentheses.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2017 American Society of Human Genetics Terms and Conditions

4. Figure 3
AAF Distribution of Pathogenic or Likely Pathogenic ClinVar Variants Predicted to Be Benign or Likely Benign by InterVar and All Pathogenic or Likely Pathogenic ClinVar Variants
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2017 American Society of Human Genetics Terms and Conditions

5. Figure 4 Illustration of wInterVar
(A) Automatic interpretation of genetic variants, which can be entered by several means.
(B) Once users click “adjust,” the full list of criteria is shown for manual adjustment, after which the final results are given.
The American Journal of Human Genetics  , DOI: ( /j.ajhg )
Copyright © 2017 American Society of Human Genetics Terms and Conditions