1. A Fat Lot of Good for Wound Healing
Alessandra Maria Casano, Michael Sixt 
Developmental Cell 
Volume 44, Issue 4, Pages (February 2018)
DOI: /j.devcel
Copyright © 2018 Elsevier Inc. Terms and Conditions

2. Figure 1 Migration and Local Functions of Fat Cells upon Injury
(A) Under homeostatic conditions, fat cells constantly form stochastic actin waves sweeping along their cell body (green shades). In response to epithelial damage, these waves coordinate and direct from the cell center to the rear (black arrows), producing peristaltic contractions that deform cell shape. Although this process does not require adhesion or friction between cells and a rigid substrate, it seems to allow cells to efficiently and directionally “swim” in a viscous extracellular environment like the hemolymph. Blue arrows indicate putative fluid vectors produced by the moving cell. (B) Once at the site of injury, fat cells extend lamellipodial protrusions and seal the wound margin, protecting it from pathogen intrusions. In addition, they interact with resident macrophages in keeping the local environment tight and clean by swiping away (and occasionally engulfing) cell debris and releasing antimicrobial peptides (AMPs, red dots) in case of microbial infestation (green rods).
Developmental Cell  , DOI: ( /j.devcel )
Copyright © 2018 Elsevier Inc. Terms and Conditions