1. In early phases, Langerhans cell histiocytosis is characterised by a) bronchiocentric collection of peculiar macrophages with prominent grooves accompanied by smokers’ macrophages and eosinophils, leading to b) cellular bronchiolar nodules with irregular, s...
In early phases, Langerhans cell histiocytosis is characterised by a) bronchiocentric collection of peculiar macrophages with prominent grooves accompanied by smokers’ macrophages and eosinophils, leading to b) cellular bronchiolar nodules with irregular, stellate-shaped margins; c) Langerhans cell histiocytes express CD1a at immunohistochemistry; d) during disease progression, the nodules tend to form central cavitation surrounded by fibrosis and decrease of Langerhans cells; e) the disease generally has a good prognosis, leaving hypocellular bronchiolocentric scars of dense fibrosis without Langerhans cells. Images courtesy of T.V. Colby, from the Charles B. Carrington Collection, sited at the Dept of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA.
Giulio Rossi et al. Eur Respir Rev 2017;26:170009
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