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High MET Receptor Expression But Not Gene Amplification in ALK 2p23 Rearrangement Positive Non–Small-Cell Lung Cancer  Yan Feng, MD, Eugen C. Minca, MD,

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Presentation on theme: "High MET Receptor Expression But Not Gene Amplification in ALK 2p23 Rearrangement Positive Non–Small-Cell Lung Cancer  Yan Feng, MD, Eugen C. Minca, MD,"— Presentation transcript:

1 High MET Receptor Expression But Not Gene Amplification in ALK 2p23 Rearrangement Positive Non–Small-Cell Lung Cancer  Yan Feng, MD, Eugen C. Minca, MD, Christopher Lanigan, MS, Angen Liu, MD, PhD, Wei Zhang, MS, Lihong Yin, PhD, Nathan A. Pennell, MD, PhD, Carol Farver, MD, Raymond Tubbs, DO, Patrick C. Ma, MD, MSc  Journal of Thoracic Oncology  Volume 9, Issue 5, Pages (May 2014) DOI: /JTO Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Representative examples of MET immunohistochemical staining with score 0–3 using SP44 monoclonal rabbit anti-Total c-Met (Ventana Medical Systems). The pattern of immunostaining was both cytoplasmic and membranous. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Distribution of MET IHC signal intensity in ALK(−) and ALK(+) NSCLC. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Representative examples of HGF IHC staining with score 0 to 3 using a human HGF affinity purified goat polyclonal antibody (R&D). The pattern of immunostaining was mainly cytoplasmic. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Distribution of HGF IHC signal intensity in ALK(−) and ALK(+) NSCLC. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Representative examples of MET gene amplification by dual probe (black MET probe and red Chromosome 7 probe), dual hapten bright field in situ hybridization (DDISH). MET gene amplification is defined as the ratio of MET/Chromosome 7 ≥ 2.0. Journal of Thoracic Oncology 2014 9, DOI: ( /JTO ) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

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