1. 2010 Update from the IACUC

2. Change in Committee Composition Effective July 1, 2010 Jeff Henegar, Ph.D. – Chair Pathology Phone: 984-1572 email: jhenegar@umc.edujhenegar@umc.edu 1 new member 4 members rotated off

3. New/Updated Policies Guidelines for submission and review of protocols to the IACUC Approved 1/19/10 Guidelines for submission and review of protocols to the IACUC Quarantine Procedures for Rodents from Non- Commercial Sources Approved 12/17/09 Quarantine Procedures for Rodents from Non- Commercial Sources Management of Supected Protocol Noncompliance - now includes list of Animal Research Related Issues of Noncompliance Management of Supected Protocol Noncompliance

4. Change in Policy One time 10% increase granted by chair now applies only to mice and rats All other species requires full committee review Required by OLAW in our Animal Welfare Assurance

5. Animal Activity Protocol Form Updated 10/2009 Effective 1/2010 – Investigators are required to submit protocols on updated form The format of the Assurance/Search/Narrative section has been changed to assist investigators in providing the necessary information required by the USDA and OLAW regulations. The Roland Medical Library reference desk (ext. 4-1231) is available to provide additional assistance with protocol searches, if needed.

6. Assurance/Search/Narrative Search should address alternatives to potentially painful and/or distressful procedures Search of 2 databases required Narrative should address 3 Rs: refinement, reduction, replacement

7. Center for Biostatistics Option available for assistance with minimizing animal numbers necessary for obtaining valid results Interested investigators are encouraged to contact the Center's director Michael Griswold at mgriswold@dor.umsmed.edu to set up an initial meeting. mgriswold@dor.umsmed.edu http://research.umc.edu/Bio- Statistics/UMC_Biostatistics-summary.html http://research.umc.edu/Bio- Statistics/UMC_Biostatistics-summary.html

8. Protocol Compliance Please adhere to IACUC approved protocols It is necessary to modify the protocol as research plans evolve prior to initiating the activities

9. Pharmaceutical-grade Compounds Pharmaceutical-grade compounds should be used unless unavailable or scientifically justified and approved by the IACUC. NIH policy online at http://oacu.od.nih.gov/ARAC/documents/Pharmac eutical_Compounds.pdf http://oacu.od.nih.gov/ARAC/documents/Pharmac eutical_Compounds.pdf

10. Guide for Care and Use of Laboratory Animals 8 th edition Last update was in 1996 Additions to this eighth edition of the Guide include expanded coverage of the ethics of laboratory animal use; components of effective animal care and use Programs; and new guidelines for the housing, environment, and enrichment of terrestrial and aquatic animals, and for veterinary and clinical care. – National Academies Report

11. Environmental Enrichment The AWR (section 3.81) provide detailed information about enrichment plan specifically for nonhuman primates The Guide of the Care and Use of Laboratory Animals, 2010 offers a greatly expanded section on Environmental Enrichment dealing with all vertebrate species

12. Chemical Hazards The Office of Environmental Health and Safety has issued Standard Operating Procedures (SOPs) for handling of the following chemical hazards:Office of Environmental Health and Safety Vincristine Sulfate BrdU MPTP STZ LPS Paraquart Dichloride MS-222

13. Material Safety Data Sheets MSDS On-line Available on Intranet under Hot Spots

14. Post-operative/Post-procedural Monitoring Monitor and document recovery of animals If animal is not recovering, contact veterinary staff for assistance