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Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic.

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Presentation on theme: "Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic."— Presentation transcript:

1 Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic recruitment and derecruitment  K.U. Klein, S. Boehme, E.K. Hartmann, M. Szczyrba, L. Heylen, T. Liu, M. David, C. Werner, K. Markstaller, K. Engelhard  British Journal of Anaesthesia  Volume 110, Issue 2, Pages (February 2013) DOI: /bja/aes376 Copyright © 2013 The Author(s) Terms and Conditions

2 Fig 1 Baseline measurements of systemic (PaO2, AP) and cerebral parameters (PbrO2, CBF) over time. No dependency on the rate of respiration could be observed; AP, arterial pressure; CBF, cerebral blood flow; PaO2, arterial oxygen partial pressure; PbrO2, cerebral subcortical partial pressure of oxygen. British Journal of Anaesthesia  , DOI: ( /bja/aes376) Copyright © 2013 The Author(s) Terms and Conditions

3 Fig 2 Respiratory-dependent oscillations in systemic (PaO2, AP) and cerebral (PbrO2, CBF) oxygenation during cyclic R/D. AP, arterial pressure; CBF, cerebral blood flow; cyclic R/D, cyclic recruitment and derecruitment; PaO2, arterial oxygen partial pressure; PbrO2, cerebral subcortical partial pressure of oxygen. British Journal of Anaesthesia  , DOI: ( /bja/aes376) Copyright © 2013 The Author(s) Terms and Conditions

4 Fig 3 Amplitudes of oxygen oscillations (PaO2, SpO2, PbrO2, SbrO2) during cyclic R/D at FIO2 1.0 (saturated haemoglobin) or 0.3 (desaturated haemoglobin). Data are presented as mean (sd). Comparisons between FIO2 1.0 and 0.3 were performed by the Mann–Whitney test; cyclic R/D, cyclic recruitment and derecruitment; FIO2, fraction of inspired oxygen; PaO2, arterial oxygen partial pressure; PbrO2, cerebral subcortical partial pressure of oxygen; SbrO2, cerebral cortical haemoglobin oxygen saturation; SpO2, peripheral haemoglobin oxygen saturation. British Journal of Anaesthesia  , DOI: ( /bja/aes376) Copyright © 2013 The Author(s) Terms and Conditions

5 Fig 4 Phase shifts of cerebral measurements (PbrO2, SbrO2, CBF) referenced to PaO2oscillations during cyclic R/D. Data are presented as mean (sd); CBF, cerebral blood flow; cyclic R/D, cyclic recruitment and derecruitment; PaO2, arterial oxygen partial pressure; PbrO2, cerebral subcortical partial pressure of oxygen; SbrO2, cerebral cortical haemoglobin oxygen saturation. British Journal of Anaesthesia  , DOI: ( /bja/aes376) Copyright © 2013 The Author(s) Terms and Conditions


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