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PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

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Presentation on theme: "PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria"— Presentation transcript:

1 PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria
Peter D. Crompton, Susan K. Pierce  Immunity  Volume 45, Issue 2, Pages (August 2016) DOI: /j.immuni Copyright © Terms and Conditions

2 Figure 1 PD-L2 Can Enhance T Cell Activation in Plasmodium-Infected Mice During malaria infection in humans, higher PD-L2 expression on DCs correlates with lower parasitemia. In mice, PD-L2 enhances CD4+ T cell immunity to malaria by competing with PD-L1 to diminish PD-1-mediated inhibition of T cell activation. Immunity  , DOI: ( /j.immuni ) Copyright © Terms and Conditions


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