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Stressing out the Social Network

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Presentation on theme: "Stressing out the Social Network"— Presentation transcript:

1 Stressing out the Social Network
Lowry A. Kirkby, Vikaas S. Sohal  Neuron  Volume 91, Issue 2, Pages (July 2016) DOI: /j.neuron Copyright © Terms and Conditions

2 Figure 1 Understanding Network Changes Associated with Abnormal Social Behavior in Stress-Susceptible Mice After exposure to a chronic social defeat paradigm, mice are classified as resilient or susceptible, based on their behavior in a social assay. Prefrontal local field potential (LFP) power in the β band (14–23 Hz) correlates with β-frequency synchronization between the amygdala (AMY) and ventral tegmental area (VTA); furthermore, spiking of many prefrontal units correlates with periods of AMY-VTA synchronization. This coupling (between PFC β-power and AMY-VTA β-coherence) is decreased in the setting of social behavior, particularly in stress-susceptible mice (negative reactivity). Furthermore, chemogenetic manipulations that exacerbate (normalize) this change in network function disrupt (rescue) normal social behavior, suggesting an important role for this network change in social behavior. Neuron  , DOI: ( /j.neuron ) Copyright © Terms and Conditions

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