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Joel D. Kopple, Kamyar Kalantar-Zadeh, Rajnish Mehrotra 

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Presentation on theme: "Joel D. Kopple, Kamyar Kalantar-Zadeh, Rajnish Mehrotra "— Presentation transcript:

1 Risks of chronic metabolic acidosis in patients with chronic kidney disease 
Joel D. Kopple, Kamyar Kalantar-Zadeh, Rajnish Mehrotra  Kidney International  Volume 67, Pages S21-S27 (June 2005) DOI: /j x Copyright © 2005 International Society of Nephrology Terms and Conditions

2 Figure 1 Nitrogen and potassium balance in 6 nondialyzed uremic patients pre- and postsupplementation with sodium bicarbonate. (From4). Kidney International  , S21-S27DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

3 Figure 2 Branched chain amino acid levels measured in 9 hemodialysis patients before and after 6 months of bicarbonate treatment. A significant increase in the concentration of valine, leucine, and isoleucine was seen on correction of the metabolic acidosis. (From4). Kidney International  , S21-S27DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

4 Figure 3 Mechanisms by which metabolic acidosis may induce protein energy malnutrition. (From3). Kidney International  , S21-S27DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions

5 Figure 4 The various mechanisms by which metabolic acidosis may contribute to bone disease. (From3). Kidney International  , S21-S27DOI: ( /j x) Copyright © 2005 International Society of Nephrology Terms and Conditions


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