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Volume 60, Issue 6, Pages (December 2001)

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Presentation on theme: "Volume 60, Issue 6, Pages (December 2001)"— Presentation transcript:

1 Volume 60, Issue 6, Pages 2164-2172 (December 2001)
Positive effect of the induction of p21WAF1/CIP1 on the course of ischemic acute renal failure  Judit Megyesi, Lucia Andrade, Jose M. Vieira, Robert L. Safirstein, Peter M. Price  Kidney International  Volume 60, Issue 6, Pages (December 2001) DOI: /j x Copyright © 2001 International Society of Nephrology Terms and Conditions

2 Figure 1 Expression of p21 after renal ischemia. Immunohistochemical localization of p21 protein in kidney nuclei after 50 minutes of renal ischemia. Sections represent kidney from untreated (A) mice, and from mice 1 day (B), 2 days (C), and 5 days (D) after ischemia. Magnification ×122. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

3 Figure 2 Kaplan-Meier survival curve. Comparison of the survival of p21(+/+) and p21(-/-) mice after 30 and 50 minutes of renal ischemia. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

4 Figure 3 Renal function evaluation after ischemia. Urea nitrogen levels in serum (BUN) after 30 and 50 minutes of ischemia. Values (mg/dL) at each time point represent means (± SE) of at least six mice. Statistically significant differences (P < 0.05) are indicated. Symbols are: (▪) p21(-/-); () p21(+/+). Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

5 Figure 4 Comparison of kidney morphology. Hematoxylin-eosin stained kidney sections from p21(+/+) (A–D) and p21(-/-) (D–F) mice. Sections represent kidney from untreated mice (A and D), and mice 1 day (B and E), and 7 days (C and F) after renal ischemia. Magnification ×122. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions

6 Figure 5 Cell-cycle analysis of kidney after cisplatin injection. Immunolocalization of nuclear PCNA in kidney sections from p21(+/+) (A–D) and p21(-/-) (E–H) mice. Sections represent kidney from untreated mice (A and E), and mice 1 day (B and F), 2 days (C and G), and 7 days (D and H) after renal ischemia. Magnification ×122. Kidney International  , DOI: ( /j x) Copyright © 2001 International Society of Nephrology Terms and Conditions


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