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Volume 13, Issue 1, Pages (January 2012)

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1 Volume 13, Issue 1, Pages 65-77 (January 2012)
Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study  Dr Gillian C Barnett, BM BCh, Charlotte E Coles, PhD, Rebecca M Elliott, MRes, Caroline Baynes, Craig Luccarini, BSc, Don Conroy, Jennifer S Wilkinson, BSc, Jonathan Tyrer, PhD, Vivek Misra, MB BS, Radka Platte, BSc, Sarah L Gulliford, PhD, Matthew R Sydes, MSc, Emma Hall, PhD, Prof Søren M Bentzen, PhD, Prof David P Dearnaley, MD, Neil G Burnet, PhD, Paul DP Pharoah, PhD, Alison M Dunning, PhD, Prof Catharine ML West, PhD  The Lancet Oncology  Volume 13, Issue 1, Pages (January 2012) DOI: /S (11) Copyright © 2012 Elsevier Ltd Terms and Conditions

2 Figure 1 Trial profile IMRT=intensity modulated radiotherapy. *One patient was not randomised because the standard plan was unacceptable, owing to a significant region of low dose, so IMRT was prescribed; patient was withdrawn from the late toxicity analysis. The Lancet Oncology  , 65-77DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions

3 Figure 2 Q-Q plots showing p values (and corresponding χ2 values) obtained from (A) univariate and (B) multivariable analyses of overall toxicity against genotype at the 92 SNPs The solid lines represent the identity line (x=y). p values do not vary significantly from those that would be expected from chance alone. SNP=single nucleotide polymorphism. df=degree of freedom. The Lancet Oncology  , 65-77DOI: ( /S (11) ) Copyright © 2012 Elsevier Ltd Terms and Conditions


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