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Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based.

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Presentation on theme: "Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based."— Presentation transcript:

1 Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)  V.B. Kraus, P.G. Conaghan, H.A. Aazami, P. Mehra, A.J. Kivitz, J. Lufkin, J. Hauben, J.R. Johnson, N. Bodick  Osteoarthritis and Cartilage  Volume 26, Issue 1, Pages (January 2018) DOI: /j.joca Copyright © 2017 The Authors Terms and Conditions

2 Fig. 1 Patient disposition. D/C – discontinuation, LTFU – lost to follow-up. Osteoarthritis and Cartilage  , 34-42DOI: ( /j.joca ) Copyright © 2017 The Authors Terms and Conditions

3 Fig. 2 SF TA concentrations (log-linear scale) over time following a single IA injection of FX006 or TAcs. To obtain a reasonable estimate of the GM SF values, a scaler value of 1 was added to each observed concentration value. CI – confidence interval. Osteoarthritis and Cartilage  , 34-42DOI: ( /j.joca ) Copyright © 2017 The Authors Terms and Conditions

4 Fig. 3 Blood plasma TA concentrations (log-linear scale) over time following a single IA injection of FX006 or TAcs. Osteoarthritis and Cartilage  , 34-42DOI: ( /j.joca ) Copyright © 2017 The Authors Terms and Conditions


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