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Volume 138, Issue 5, Pages e13 (May 2010)

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Presentation on theme: "Volume 138, Issue 5, Pages e13 (May 2010)"— Presentation transcript:

1 Volume 138, Issue 5, Pages 1714-1726.e13 (May 2010)
Meta-analysis Shows That Detection of Circulating Tumor Cells Indicates Poor Prognosis in Patients With Colorectal Cancer  Nuh N. Rahbari, Maximilian Aigner, Kristian Thorlund, Nathan Mollberg, Edith Motschall, Katrin Jensen, Markus K. Diener, Markus W. Büchler, Moritz Koch, Jürgen Weitz  Gastroenterology  Volume 138, Issue 5, Pages e13 (May 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Selection of studies.
Gastroenterology  , e13DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Summary estimates of hazard ratio (HR) for (A) disease recurrence and (B) death associated with hematogenous tumor cell detection. RFS, recurrence-free survival; OS, overall survival. Note: Three studies reported cancer-related survival (CRS) instead of OS.17,20,39 Sensitivity analysis excluding these studies did not change the results significantly (HR = 2.44 [95% CI: 1.60–3.74], n = 18, I2 = 67%). Gastroenterology  , e13DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Summary estimates of hazard ratio (HR) for disease recurrence and death associated with tumor cell detection in the (A and D) peripheral blood, (B and E) mesenteric/portal blood, and (C and F) bone marrow compartment. RFS, recurrence-free survival; OS, overall survival. Note: Two studies in the analysis of peripheral blood (D) reported cancer-related survival (CRS) instead of OS.17,20 Sensitivity analysis excluding these studies did not change the results significantly (HR = 2.73 [95% CI: 1.68–4.45], n = 14, I2 = 63%). Gastroenterology  , e13DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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