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Hello, my name is Attakias and today I will be presenting a study on…

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Presentation on theme: "Hello, my name is Attakias and today I will be presenting a study on…"— Presentation transcript:

1 The Possible Cognitive Confound in Olfactory Testing for Parkinson’s Disease
Hello, my name is Attakias and today I will be presenting a study on… Attakias Mertens, Department of Psychology Dr. Bruce Chase, Department of Biology

2 Parkinson’s disease 2nd most common neurodegenerative disease
Diagnosis involves motor symptoms Earlier and more accurate diagnosis needed Looking to non-motor symptoms Often these motor symptoms can reflect later stages in disease progression.

3 Olfactory dysfunction
Olfactory dysfunction occurs prior to motor symptoms Used as diagnostic aid Cause of dysfunction unknown Reason unknown. Declines in normal aging too. Such as the Thalamus… And the Hippocampus…

4 Electroencephalogram (EEG) Recording
Aim of Study Investigate activity of cognitive pathways during olfactory perception (smelling) and processing Patients with PD Cognitive Assessment Assess if cognitive functioning has an impact on olfactory processing electroencephalogram recording during participants’ olfactory testing to observe if cortical activity associated with cognitive domains varies between age and sex matched healthy controls and patients with Parkinson’s disease. Along with this, another comparison group of young healthy adults has been added to assess differences along the path of healthy aging, as olfactory decline is also seen here. Age and Sex-matched Healthy Controls Tests of olfaction Younger Healthy Controls Electroencephalogram (EEG) Recording

5 Montreal Cognitive Assessment (MoCA)
Test of global cognition Used to assess for Mild Cognitive Impairment Organized into subsections of cognitive domains

6 Measures of Olfaction Sniffin’ Sticks Threshold Discrimination
Identification

7 Electroencephalogram (EEG)

8 Eeg testing cognition EEG Cognitive and memory activity
Contributions to Parkinson’s disease non-dopamanergic

9 Preliminary olfactory results

10 Conclusion & project projections
Current findings support previous findings EEG data analysis underway Further subject testing anticipated [Geraedts, et al., 2018] [Klimesch, 1999]

11 Thank you Acknowledgements:
The Office of Research and Creative Activity (ORCA) for supporting this research through a Graduate Research and Creative Activity (GRACA) grant

12 References Geraedts, V. J., Marinus, J., Gouw, A. A., Mosch, A., Stam, C. J., van Hilten, J. J., ... & Tannemaat, M. R. (2018). Quantitative EEG reflects non-dopaminergic disease severity in Parkinson’s disease. Clinical Neurophysiology, 129(8), Klimesch, W. (1999). EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain research reviews, 29(2-3),

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