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Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury  Jill M. Wecht, EdD, Dwindally.

Published byVictorien Dumouchel Modified over 5 years ago

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Presentation on theme: "Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury  Jill M. Wecht, EdD, Dwindally."— Presentation transcript:

1 Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury  Jill M. Wecht, EdD, Dwindally Rosado-Rivera, EdD, Joseph P. Weir, PhD, Adrian Ivan, MS, Christina Yen, BS, William A. Bauman, MD  Archives of Physical Medicine and Rehabilitation  Volume 94, Issue 10, Pages (October 2013) DOI: /j.apmr Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

2 Fig 1 BL and supine observations for heart rate (A), SBP (B), and DBP (C); placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). ↑=administration of placebo/droxidopa. The main effect for dose and the interaction effect were not significant; however, the main effect for position was significant for heart rate, SBP, and DBP: *P<.0001 compared with BL 1, 2, and 3. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

3 Fig 2 Individual responses to the orthostatic change in heart rate (A), SBP (B), and DBP (C) when repositioning from supine to seated; placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). Main effects for dose and position and the interaction effect were not significant. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

4 Fig 3 Seated BL and seated postdrug/placebo heart rate (A), SBP (B), and DBP (C); placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). *P<.05 versus placebo; τ=P<.05 versus 100mg droxidopa; δ=P<.05 versus 200mg droxidopa. Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

5 Fig 4 Average 4-hour SBP following placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). The dashed line represents the WHO's threshold for hypotension in males (110mmHg). Archives of Physical Medicine and Rehabilitation  , DOI: ( /j.apmr ) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

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