1. Molecular Machines (Jacobson) Group
red blood cell
~5 m (SEM)
diatom
30 m
Simple molecules
<1nm
DNA
proteins nm
bacteria
1 m
10-10
10-5
10-9
10-7
10-6
10-8
10-4
10-3
10-2 m
SOI transistor
width 0.12m
semiconductor
nanocrystal (CdSe)
2nm
Circuit design
Copper wiring
width 0.2m
Nanometer memory element
(Lieber)
1012 bits/cm2 (1Tbit/cm2)
IBM PowerPC 750TM Microprocessor
7.56mm×8.799mm
6.35×106 transistors

2. Ffab = ln (W) / [ a3 tfab Efab ]
Fabrication Figure of Merit
Ffab = ln (W) / [ a3 tfab Efab ]

3. All Printed-All Inorganic 3D
Fab in a Box
NanoTectonics
All Printed-All Inorganic 3D
nm Building Blocks – Seconds Per Layer
Nanocluster Building Blocks
Liquid Processed Chips
Multilayer Liquid Assembly
TFT Devices
Ridley et. Al, Science, 286, 746 (1999)
Bulthaup et. Al. APL 79(10): 1525 (2001)
Molecular Machines (Jacobson) Group

4. Molecular Machines Richard P. Feynman (1918-1988)
There is Plenty of Room at the Bottom, December 29th,
What I want to talk about is the problem of manipulating and controlling things on a small scale.
As soon as I mention this, people tell me about miniaturization, and how far it has progressed today. They tell me about electric motors that are the size of the nail on your small finger. And there is a device on the market, they tell me, by which you can write the Lord's Prayer on the head of a pin. But that's nothing; that's the most primitive, halting step in the direction I intend to discuss. It is a staggeringly small world that is below. In the year 2000, when they look back at this age, they will wonder why it was not until the year 1960 that anybody began seriously to move in this direction…..
It is remarkable that given enough time, the synthetic chemist can usually synthesize what they set out to make.
Richard P. Feynman ( )

5. Matthew C. T. Fyfe and J. Fraser Stoddart*
Acc. Chem. Res., 30 (10), , /ar950199y S (95)
Copyright © 1997 American Chemical Society
Synthetic Supramolecular Chemistry
Matthew C. T. Fyfe and J. Fraser Stoddart*

6. ATP Synthase
Molecular Architecture of the Rotary Motor in ATP Synthase
Daniela Stock, Andrew G. W. Leslie, and John E. Walker Science Nov :

7. BioMolecular Machines
Why They And Their Synthetic Analogs Are The Next Revolution
- Bypass Moore’s Law: Extremum in Cost / Size / Yield
Combinatorically Interchangeable Parts
Self Replicating

8. Radio Frequency Control of Biomolecular Machines
Molecular Machine (Jacobson/Hamad) Group
Center for Biomedical Engineering (Zhang)
MIT
Hamad-Schifferli Nature 415 (6868), 152 (2002)