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Published byElisa Chávez Modified over 5 years ago
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Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent Marialbert Acosta-Herrera, MSc, Maria Pino-Yanes, PhD, Shwu-Fan Ma, PhD, Amalia Barreto-Luis, BS, Almudena Corrales, CLT, José Cumplido, MD, Eva Pérez-Rodríguez, MD, Paloma Campo, MD, PhD, Celeste Eng, BS, José Carlos García-Robaina, MD, PhD, Inés Quintela, MSc, Jesús Villar, MD, PhD, Miguel Blanca, MD, PhD, Ángel Carracedo, MD, PhD, Teresa Carrillo, MD, PhD, Joe G.N. Garcia, MD, Dara G. Torgerson, PhD, Esteban G. Burchard, MD, MPH, Carlos Flores, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 4, Pages e9 (October 2015) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Regional plots of association results in the discovery sample (upper panel) and the GABRIEL (middle panel) and EVE (lower panel) consortia. The −log10 transformed P values for association tests are plotted as symbols according to their functional annotation. The SNP rs number indicated on the plot denotes the result for the most significantly associated SNP with asthma risk. The results for the remaining SNPs are color coded to reflect their degree of LD with the most significant SNP based on pairwise r2 values from the European population of the 1KGP. Estimated recombination rates (light blue line) are plotted on the right y-axis. Journal of Allergy and Clinical Immunology , e9DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig E1 Flow chart providing an overall description of the study design. GALA I, Genetics of Asthma in Latino Americans; GALA II, Genes-Environments & Admixture in Latino Americans; GOA I, Genetics of Asthma study in the Spanish population; GOA II, Genetics of Asthma study in the Spanish population II; GOAM, Genetics of Asthma study in the Spanish population from Malaga. Journal of Allergy and Clinical Immunology , e9DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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