1. Radiation damage at cellular and DNA level
Petteri Nieminen
ESA/ESTEC
Maria Grazia Pia
INFN Genova and CERN

2. Simulation of radiation damage at cellular level
Geant3 (and other legacy packages)
traditional “digitization-style” approach
physics processes generate macroscopic quantities (dose)
interfaced to independent parameterised models to evaluate cell damage, cell survival etc.
Geant4
native approach, thanks to Geant4 powerful OO design
capability to model DNA as a “geometry” in Geant4
capability to handle biochemical processes in Geant4
Geant4-DNA Collaboration
ESA General Study, in collaboration with INFN

3. Astronaut safety, exobiology
ESA Space Environment &
Effects Analysis Section
Interactions of radiation with biological systems at cellular and DNA level
a, C, Fe, ...
New Geant4 -based activity in the ESA General Studies Programme
Biological and chemical factors...
Contractor INFN Genova; network of 20 scientists at INFN, CERN, ESA, and the Italian National Institute for Cancer Research
Heavy ions particularly harmful
Astronaut safety,
exobiology