1. A Hen in the Wolf Den: A Pathobiont Tale
Matteo M. Guerrini, Alexis Vogelzang, Sidonia Fagarasan 
Immunity 
Volume 48, Issue 4, Pages (April 2018)
DOI: /j.immuni
Copyright © 2018 Elsevier Inc. Terms and Conditions

2. Figure 1
Translocation of the Gut Commensal Bacterium Enterococcus gallinarum Triggers the Onset of Systemic Lupus Erythematosus in the (NZW × BXSB) F1 Strain of Lupus-Prone Mice
The gut of lupus-prone mice is characterized by compromised barrier function, reduced mucus expression, and an imbalance of microbial diversity, resulting in bacterial translocation. In the lamina propria of the small intestine, E. gallinarum induces an increase of plasmacytoid dendritic cells (pDCs) that produce IFNα. E. gallinarum produces AhR ligands, which enhance Th17 and T follicular helper (Tfh) cell activation and differentiation. In the liver, E. gallinarum induces expression of lupus-specific autoantigens and inflammatory factors, enhancing pathogenic deposition of immune complexes in multiple organs.
Immunity  , DOI: ( /j.immuni )
Copyright © 2018 Elsevier Inc. Terms and Conditions