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RA Gets Out of the Way to Allow High-Acuity Vision

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Presentation on theme: "RA Gets Out of the Way to Allow High-Acuity Vision"— Presentation transcript:

1 RA Gets Out of the Way to Allow High-Acuity Vision
Adele Tufford, Michel Cayouette  Developmental Cell  Volume 42, Issue 1, Pages 3-5 (July 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 Retinoic Acid and FGF8 Pattern the Chick HAA
(A) Wild-type retinas possess a cone-dense high-acuity area (HAA), where rods are entirely excluded due to elevated FGF8 in the HAA anlage and local exclusion of retinoic acid (RA) signaling. Rods are present in a ventral-high/dorsal-low gradient in the chick retina. (B) Experimental elevation of RA or FGF8 knockdown leads to the presence of rods in the HAA. (C) Retinoic acid is present outside the HAA and may directly or indirectly repress FGF8 expression. By a still-unknown mechanism, expression of FGF8 and the RA-degrading enzyme CYP26A become restricted to a focal area, allowing formation of the HAA. Developmental Cell  , 3-5DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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