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Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats P. Lirk, C. Verhamme, R. Boeckh, M.F. Stevens, W. ten Hoope, P. Gerner, S. Blumenthal, U. de Girolami, I.N. van Schaik, M.W. Hollmann, S. Picardi British Journal of Anaesthesia Volume 114, Issue 2, Pages (February 2015) DOI: /bja/aeu270 Copyright © 2015 The Author(s) Terms and Conditions
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Fig 1 Timeline of experimental interventions.
British Journal of Anaesthesia , DOI: ( /bja/aeu270) Copyright © 2015 The Author(s) Terms and Conditions
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Fig 2 Development of sensible conduction velocity (a) and minimal F-wave latency (b) over time in the three experimental groups. After nerve block, conduction velocity tended to decline in all groups, but did not reach statistical significance when groups were pooled (P=0.15). Sciatic nerve motor block duration in late diabetic animals (c). After the nerve block, the minimal F-wave latency increased significantly, when the data of all three groups were pooled. Data are shown as mean and sd. anova with the post hoc Bonferroni test, paired samples T-test. *P<0.05; #P<0.01; ##P<0.001. British Journal of Anaesthesia , DOI: ( /bja/aeu270) Copyright © 2015 The Author(s) Terms and Conditions
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Fig 3 Neurohistopathology of a representative healthy control nerve (a), and a nerve from a representative diabetic animal, showing focal areas of acute myelin injury and axonal damage, associated with scattered chronic inflammatory cells (b). British Journal of Anaesthesia , DOI: ( /bja/aeu270) Copyright © 2015 The Author(s) Terms and Conditions
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