1. miRNA Profiling Identifies Candidate miRNAs for Bladder Cancer Diagnosis and Clinical Outcome 
Nadine Ratert, Hellmuth-Alexander Meyer, Monika Jung, Poline Lioudmer, Hans-Joachim Mollenkopf, Ina Wagner, Kurt Miller, Ergin Kilic, Andreas Erbersdobler, Steffen Weikert, Klaus Jung 
The Journal of Molecular Diagnostics 
Volume 15, Issue 5, Pages (September 2013)
DOI: /j.jmoldx
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2. Figure 1
The miRNA expression in 57 tissue samples from nonmalignant and malignant bladder cancer. The expression of seven up-regulated miRNAs (A) and eight down-regulated (B) miRNAs is shown. The white columns are the nonmalignant tissues (n = 17). The light gray columns are the NMIBCs (n = 25). The dark gray columns are the MIBCs (n = 15). These columns depict medians with 95% confidence intervals determined by bootstrapping with 2000 re-samples. For the sake of completeness, we also include the deregulated miRNA data of miR-20a and miR-200a, which was previously reported.21 The expression was normalized against the reference miRNA combination of miR-101, miR-148b, miR-125a-5p, and miR-151-5p.21 For all miRNAs, the Kruskal-Wallis test was always statistically significant (P < ). Statistical differences between the three groups were pairwise calculated by the U-test and are indicated by asterisks. ∗P < , ∗∗P < , and ∗∗∗P < based on the Bonferroni correction for multiple testing.
The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx )
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3. Figure 2
Association of expression levels of miR-141 and miR-205 in malignant tissue samples, as determined by real-time RT-qPCR with overall survival time. Kaplan-Meier analysis correlating overall survival time as a function of miR-141 (A; log-rank test; P = 0.02) or miR-205 (B; log-rank test; P = 0.04) expression in tumor samples (n = 40). The overall survival time is defined as months elapsed between transurethral resection or radical cystectomy and death or the last follow-up date. Statistical significance is defined as P < RTX, radical cystectomy; TURB, transurethral resection.
The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx )
Copyright © 2013 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions