1. 580.704 Mathematical Foundations of BME Reza Shadmehr
Maximum likelihood
Integration of sensory modalities

2. We showed that linear regression, steepest decent algorithm, and LMS all minimize the cost function
This is just one possible cost function. What is the justification for this cost function? Today we will see that this cost function gives rise to the maximum likelihood estimate if the data is normally distributed.

3. Expected value and variance of scalar random variables

4. Statistical view of regression
Suppose the outputs y were actually produced by the process:
The “true” underlying process
What we measured
Our model of the process
Given a constant X, the underlying process would give us different y every time we observe it. Given each “batch”, we fit our parameters. What is the probability of observing the particular y in trial i?

5. Probabilistic view of linear regression
Linear regression expresses the random variable y(n) in terms of the input-independent variation e around the mean y
Let us assume: x
variance
Probability of observing some specific value of y, given that we have hypothesized model structure, a specific input x, and specific weights w. That probability will have its peak at our expectation yhat, and a variance that depends on the variance of the residual.
Normal distribution
Mean zero
Then outputs y given x are:

6. Probabilistic view of linear regression
As variance, i.e., spread, of the residual e increases, our confidence about our model’s guess decreases. 1 2 3 4 5 6
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7. Probabilistic view of linear regression
Example: suppose the underlying process was:
Given some data points, we estimate w and also guess the variance of the noise, we could compute probability of each y that we observed.
In this example,
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We want to find a set of parameters that maximize P for all the data.

8. Maximum likelihood estimation
We view the outputs y(n) as random variables that were generated by a probabilistic process that had some distribution with unknown parameters q (e.g., mean and variance). The “best” guess for q is one that maximizes the joint probability that the observed data came from that distribution.

9. Maximum likelihood estimation: uniform distribution
Suppose that n numbers y(i) were drawn from a distribution and we need to estimate the parameters of that distribution.
Suppose that the distribution was uniform.
Likelihood that the data came from a model with our specific parameter value

10. Maximum likelihood estimation: exponential distribution
Log-likelihood
An example of exponential distribution is time between two events. A Poisson process would give rise to such a probability density function.

11. Maximum likelihood estimation: Normal distribution
Now we see that if s is a constant, the log-likelihood is proportional to our cost function (the sum of squared errors!)

12. Maximum likelihood estimation: Normal distribution

13. Probabilistic view of linear regression
If we assume that y(i) are independently and identically distributed (I.I.D.), conditional on x(i), then the joint conditional distribution of the data y is obtained by taking the product of the individual conditional probabilities:
When you’ve been given a batch of data and a model, you can compute the probability of observing those data point that were given to you, given that you have input X and model w.
Given our model, we can assign a probability to our observation.
We want to find parameters that maximize the probability that we will observe data like the one that we were given.

14. Probabilistic view of linear regression
Given some data D, and two models: (w1,s) and (w2,s), the better model has the larger joint probability for the actually observed data. 8 8 6 6 4 4 2 2
Given a variance sigma, the probability density function is smaller the farther away the point is from the mean (the predicted value).
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15. Probabilistic view of linear regression
Given some data D, and two models: (w,s1) and (w,s2), the better model has the larger joint probability for the actually observed data. 7 10
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The underlying process here was generated with a s=1, our model was second order, and our joint probability on this data set happened to peak near s=1.

16. The same underlying process will generate different D on each run, resulting in different estimates of w and s, despite the fact that the underlying process did not change.
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17. Likelihood of our model
Given some observed data:
and model structure:
Try to find the parameters w and s that maximize the joint probability over the observed data:
Likelihood that the data came from a model with our specific parameter values

18. Maximizing the likelihood
It’s easier to maximize the log of the likelihood function.
Log-likelihood
So minimizing this particular loss function maximizes the likelihood of our model if the data came from a probability density function that was normally distributed around our model.
Finding w to maximize the likelihood is equivalent to finding w so to minimize loss function:

19. Finding weights that maximize the likelihood
Log-likelihood
(mx1)
(nxm)
(all remaining terms are scalars)
Above is the ML estimate of w, given model:

20. Finding the noise variance that maximizes the likelihood
Above is the ML estimate of s2, given model:

21. The hiking in the woods problem: combining information from various sources
We have gone on a hiking trip and taken with us two GPS devices, one from a European manufacturer, and the other from a US manufacturer. These devices use different satellites for positioning. Our objective is to figure out how to combine the information from the two sensors.
(a 4x1 vector)
Likelihood function
We want to find the position x that maximizes this likelihood.

22. Our most likely location is one that weighs the reading from each device by the inverse of the device’s probability covariance. In other words, we should discount the reading from each device according to the inverse of each device’s uncertainty.
If we stay still and do not move, the variance in our readings is simply due to noise in the devices.
By combining the information from the two devices, the variance of our estimate is less than the variance of each device.

23. ML estimate

24. Marc Ernst and Marty Banks (2002) were first to demonstrate that when our brain makes a decision about a physical property of an object, it does so by combining various sensory information about that object in a way that is consistent with maximum likelihood state estimation.
Ernst and Banks began by considering a hypothetical situation in which one has to estimate the height of an object. Suppose that you use your index and thumb to hold an object. Your haptic system and your visual system report its height.
If the noise in the two sensors is equal, then the weights that you apply to the sensors are equal as well. This case is illustrated in the left column of next figure. On the other hand, if the noise is larger for proprioception, your uncertainty is greater for that sensor and so you apply a smaller weight to its reading (right column of next fig).

25. Equal uncertainty in vision and prop.
More uncertain of proprioception

26. Measuring the noise in a biological sensor
If one was to ask you to report the height of the object, of course you would not report your belief as a probability distribution. To estimate this distribution, Ernst and Banks acquired a psychometric function, shown in the lower part of the graph. To acquire this function, they provided their subjects a standard object of height 5.5cm. They then presented a second object of variable length and asked whether it was taller than the first object. If the subject represented the height of the standard object with a maximum likelihood estimate, then the probability of classifying the second object as being taller is simply the cumulative probability distribution. This is called a psychometric function. The point of subject equality (PSE) is the height at which the probability function is at 0.5. 2 4 6 8 10 12
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27. The authors estimated that the noise in the haptic sense was four times larger than the noise in the visual sense.
This implies that in integrating visual and haptic information about an object, the brain should ‘weigh’ the visual information 4 times are much as haptic information.
To test for this, subjects were presented with a standard object for which the haptic information indicated a height of and visual information indicated a height of
Subjects would assign a weight of around 0.8 to the visual information and around 0.2 to the haptic information. To estimate these weights, they presented a second object (for which the haptic and visual information agreed) and ask which one was taller.

28. Summary
The “true” underlying process
What we measured
Our model of the process
ML estimate of model parameters, given X: