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Deep Dive: Examining Emerging GLP-1 RAs From a Clinical Perspective

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Presentation on theme: "Deep Dive: Examining Emerging GLP-1 RAs From a Clinical Perspective"— Presentation transcript:

1 Deep Dive: Examining Emerging GLP-1 RAs From a Clinical Perspective

2 GLP-1: Effects in Humans

3 FDA-Approved GLP-1 RAs

4 GLP-1 RAs and HbA1c Head-to-Head Trials

5 Tolerability of GLP-1 RAs

6 GLP-1 RAs in Development

7 ITCA 650 Exenatide

8 ITCA 650 Continuous Delivery of Exenatide

9 SUSTAIN-1 Once-Weekly Semaglutide Monotherapy

10 Patients Achieving < 7.0% and ≤ 6.5% HbA1c Target at Week 30

11 Patients Achieving HbA1c < 7
Patients Achieving HbA1c < 7.0% Without Severe Hypoglycemia and No Weight Gain at Week 30

12 ITCA 650: FREEDOM-1 Trial

13 CVOTs for GLP-1 RAs

14 Medication Adherence Scope of the Problem

15 Only About One-Third of Patients Are Adherent to GLP-1 RAs

16 Patient Challenges With GLP-1 RAs and Success of Treatment

17 Where Will These Emerging GLP-1 RAs Fit Into Clinical Practice in the Future?

18 Concluding Remarks

19


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