Presentation is loading. Please wait.

Presentation is loading. Please wait.

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order  Adaikalavan.

Published byJarkko Pesonen Modified over 5 years ago

Similar presentations

Presentation on theme: "A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order  Adaikalavan."— Presentation transcript:

1 A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order  Adaikalavan Ramasamy, DPhil, Ivan Curjuric, MD, Lachlan J. Coin, DPhil, Ashish Kumar, MSc, Wendy L. McArdle, PhD, Medea Imboden, PhD, Benedicte Leynaert, PhD, Manolis Kogevinas, MD, Peter Schmid-Grendelmeier, MD, Juha Pekkanen, MD, Matthias Wjst, MD, Andreas J. Bircher, MD, Ulla Sovio, PhD, Thierry Rochat, MD, Anna-Liisa Hartikainen, MD, David J. Balding, DPhil, Marjo-Riitta Jarvelin, MD, Nicole Probst-Hensch, PhD, David P. Strachan, MD, Deborah L. Jarvis, MD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 5, Pages (November 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Manhattan plots for main-effect analyses of IgE sensitization to grass and AR. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Concordance in statistical significance between AR and grass sensitization for the selected loci. Each loci is represented by the SNP with the lowest P value. The direction of association is consistent between these 2 phenotypes for the loci shown here (see Table II). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Regional association and forest plots for rs in the HLA region. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Regional association and forest plots for rs , which is near C11orf30 (chromosome 11 open reading frame 30) and LRRC32 (leucine-rich repeat containing 32). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Regional association and forest plots for rs , which is near SLC25A46 and TMEM232. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order  Adaikalavan."

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Timing of infant feeding in relation to childhood asthma and allergic diseases  Bright I. Nwaru, MPhil, PhD, Hanna-Mari Takkinen, MSc, Onni Niemelä, MD,

Timing of infant feeding in relation to childhood asthma and allergic diseases  Bright I. Nwaru, MPhil, PhD, Hanna-Mari Takkinen, MSc, Onni Niemelä, MD,
Does BCG vaccination protect against childhood asthma

Does BCG vaccination protect against childhood asthma
Can an airway challenge test predict respiratory diseases

Can an airway challenge test predict respiratory diseases
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes  Maritta Pykäläinen, MSc, Riikka Kinos, PhD,

Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes  Maritta Pykäläinen, MSc, Riikka Kinos, PhD,
Pharmacologic rationale for treating allergic and nonallergic rhinitis

Pharmacologic rationale for treating allergic and nonallergic rhinitis
Shared genetic variants suggest common pathways in allergy and autoimmune diseases  Eskil Kreiner, MD, PhD, Johannes Waage, PhD, Marie Standl, PhD, Susanne.

Shared genetic variants suggest common pathways in allergy and autoimmune diseases  Eskil Kreiner, MD, PhD, Johannes Waage, PhD, Marie Standl, PhD, Susanne.
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients  Xingnan Li, PhD, MS, Gregory A. Hawkins,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Maritta S. Jaakkola, MD, PhD, Reginald Quansah, PhD, Timo T

Maritta S. Jaakkola, MD, PhD, Reginald Quansah, PhD, Timo T
David A. Khan, MD  Journal of Allergy and Clinical Immunology 

David A. Khan, MD  Journal of Allergy and Clinical Immunology 
Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

Markus J. Ege, MD, David P. Strachan, MD, William O. C. M
Timing of infant feeding in relation to childhood asthma and allergic diseases  Bright I. Nwaru, MPhil, PhD, Hanna-Mari Takkinen, MSc, Onni Niemelä, MD,

Timing of infant feeding in relation to childhood asthma and allergic diseases  Bright I. Nwaru, MPhil, PhD, Hanna-Mari Takkinen, MSc, Onni Niemelä, MD,
Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population  Hui.

Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population  Hui.
A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom  Yize I. Wan, BMedSci, David P. Strachan,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?

Similar presentations

Ads by Google