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Ugursay Kiziltepe, MD, N. Nilufer D Turan, PhD, Unsal Han, MD, A

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Presentation on theme: "Ugursay Kiziltepe, MD, N. Nilufer D Turan, PhD, Unsal Han, MD, A"— Presentation transcript:

1 Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury 
Ugursay Kiziltepe, MD, N.Nilufer D Turan, PhD, Unsal Han, MD, A.Tulga Ulus, MD, Fatma Akar, PhD  Journal of Vascular Surgery  Volume 40, Issue 1, Pages (July 2004) DOI: /j.jvs

2 Fig 1 Histopathologic findings of anterior horn of lumbar spinal cord segments procured 48 hours after reperfusion and stained with hematoxylin-eosin. A, Normal appearance of neurons in sham operated animals (arrows, Nissl substance, ×40). B, Eosinophilic neuronal degeneration in group C, exhibiting inflammatory cell accumulation, destruction and vacuolization of the gray matter, pyknosis of neurons and capillary proliferation (single arrows, necrotic neuron bodies without Nissl substance; double arrow, new capillary vessels [neovascularization]; ×40). C, Near to normal appearance of anterior horn of lumbar spinal cord segments in group R10 with protected Nissl substance (arrows, ×400). Journal of Vascular Surgery  , DOI: ( /j.jvs )

3 Fig 1 Histopathologic findings of anterior horn of lumbar spinal cord segments procured 48 hours after reperfusion and stained with hematoxylin-eosin. A, Normal appearance of neurons in sham operated animals (arrows, Nissl substance, ×40). B, Eosinophilic neuronal degeneration in group C, exhibiting inflammatory cell accumulation, destruction and vacuolization of the gray matter, pyknosis of neurons and capillary proliferation (single arrows, necrotic neuron bodies without Nissl substance; double arrow, new capillary vessels [neovascularization]; ×40). C, Near to normal appearance of anterior horn of lumbar spinal cord segments in group R10 with protected Nissl substance (arrows, ×400). Journal of Vascular Surgery  , DOI: ( /j.jvs )

4 Fig 2 Malondialdehyde levels of lumbar spinal cord segments procured at the 48th hour of reperfusion. * P = .065, group R10 vs group S; P = .001, group R10 vs group C; P = .02, group R10 vs group R1. †P = .0005, groups R1 and R10 vs group S. Journal of Vascular Surgery  , DOI: ( /j.jvs )

5 Fig 3 Time course of nitrite/nitrate levels throughout the experiments. *NO release increased during ischemia in group R10 (P < .05 vs preischemia) whereas it decreased in group C (P < .01 vs preischemia). †When calculated absolute changes from baseline were compared, P < .05, group C vs group R; P < .01, group C vs group R10. During the postischemia phase, previously decreased NO release started to increase in group C whereas previously increased NO release decreased close to baseline values in groups R and R10 (P < .01 vs ischemia for group R). When calculated absolute changes from ischemia values were compared, P < .01, group C vs group R; P < .01, group C vs group R10. Journal of Vascular Surgery  , DOI: ( /j.jvs )

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